Our Synthesis Procedure:
Medicinal Chemistry |
Pre-Clinical Development |
Clinical Trials Phase 1-3 |
Commerical |
Contract Research
FTE
Fixed Price Basis |
Route Selection Process Development Process Optimization Critical Parameters Method Development Specifications and Development |
Method Validation CMC Preparation Site selection service In process control Stability Studies |
Technology Transfer
GMP Synthesis
Scale manufacturing |
mg |
mg to g |
g to kg |
kg to ton |
Our Main Technology:
Multi-step Organic Synthesis
Nitration
Reductions- Catalytic
Hydrogenation
High Temperature, high pressure reaction
Cryogenic capability (- 70 deg)
High vacuum distillation
Cyanation and Malonates
Halogonation
Liquid Ammonia chemistry
Main Hardwares:
Lab: 0,25 - 25 L Glass (50 reactors with a total volume of over 500 L)
30 L GL reactor, 50 L Hastelloy-C and 70 L Glass reactor.
80 L Stainless Steel reactor
Various other scale up equipment / reactors.
-1 up to 8 bar at pilot plant scale
Pressure reactors:
2 and 4 L; 40 bar, 10 L; 10 bar, 350 L; 8 ba
Pressure filters; 2 x 30 L Seitz, 60 L Seitz 100L and 200 L.
Vacuum filters; 200L (4 x )
Centrifuge; 5 kg and 90 kg.
Vacuumdrying chambers for kilogram quantities.
Pharma vacuum dryer up to tens of kilograms
Atmospherical Traydryer (50 kg).
Quality Support:
Dedicated QA QC TEAM
Expertise in HPLC, CE method development and optimization
Ability of Large Scale Purification, Concentration and Isolation
HPLC Variety of columns ranging from: — 8, 15, 30, 45 and 60 cm diameter
USP grade purified water
Membrane filtration
Various Wet Chemistry Analyses
Lyophilization
Spray drying